Cytological changes in oral epithelium due to Sudanese homemade alcoholic beverages

Resumo

The aim of this study was to assess the cytological changes
in oral epithelium that might be induced by Sudanese homemade
alcoholic beverages. Material and methods: Oral Exfoliative Cytology
(OEFC) was applied to a case control study to assess the presence
and severity of oral epithelial atypia (ET) in 300 subjects (150 alcohol
abuse individuals (cases); 150 non-alcohol abuse individuals (controls)).
All cases were using homemade alcoholic drinks, locally known as,
Aragee, Marisa and others. Five patients with oral squamous cell
carcinoma (OSCCs) were included as internal controls. Results: ET
was detected in 7 subjects and was not observed in the remaining
293. All the 7 subjects with cytological atypia were cases. Cytological
atypia were identified among those using Aragee, Marisa, and Aragee
& Marisa together, representing 53%, 28.6%, 18%.4, respectively.
Cytological atypia was found in all the 5 control cases with OSCCs.
For the cytological atypia among alcohol abuse individuals, the adjusted
OR and the 95% CI were found to be 5 (4.34-5.84) and P = 0.008.
Inflammatory cells infiltrates were identified among 21 (14%) of the
cases and only 12 (8%) of the controls and the adjusted OR and the
95% CI were found to be 5 (2.51-11.21) and P = 0.009. Conclusion:
In view of these findings, Sudanese homemade alcoholic beverages
cause oral epithelial atypical changes, which lead to oral precancerous
and cancerous lesions. OEFC is a useful procedure for detection and
assessment of oral ET.