Dental pulp stem cells in endodontic research: a promising tool for tooth tissue engineering

Resumo

Introduction: Millions of teeth are saved each year by root canal
therapy. Although current treatment modalities offer high levels of
success for many conditions, an ideal form of therapy might consist
of regenerative approaches in which diseased or necrotic pulp tissues
are removed and replaced with healthy pulp tissue to revitalize
teeth. The practice of dentistry is likely to be revolutionized by
biological therapies based on growth and differentiation factors that
accelerate and/or induce a natural biological regeneration. Literature
review: This review summarizes current knowledge, barriers, and
challenges in the clinical use of adult stem cells, scaffolds, and
growth factors for the development and evaluation of regenerative
endodontic therapies.