Assessment of plasma and salivary antioxidant status in patients with recurrent aphthous stomatitis

Resumo

Objective: The purpose of this study was to evaluate the antioxidant
levels in plasma and saliva of patients with recurrent aphthous
stomatitis (RAS) and healthy controls. Material and methods:
Forty patients with RAS and 40 health controls were included
into the study. Superoxide dismutase (SOD), catalase (CAT),
glutathione peroxidase (GSHPx) activities and uric acid (UA) levels
were measured in plasma and saliva. Chi-square and Student’s
t-test was used to estimate the significance between parameters.
P value less than 0.05 was considered statistically significant.
Results: Plasma analysis showed significantly decreased SOD
and CAT activities, and UA level in RAS patients compared to
control group. Plasma GSHPx activity was significantly higher in
RAS patients. In saliva, SOD and CAT activities, and UA levels
were significantly higher in RAS patients, while GSHPx activity
was lower compared to control. Conclusion: Plasma and saliva
antioxidant system is affected in RAS patients and both may be
considered as an appropriate indicator of antioxidant status of
body.