Application of BMP-2 for bone graft in Dentistry

Lídia Audrey Rocha Valadas Marques, Edvan Alves da Costa Júnior, Mara Assef Leitão Lotif, Edilson Martins Rodrigues Neto, Francisco Filipe Carvalho da Silva, Carlos Ricardo de Queiroz Martiniano


Introduction: The global increase life expectancy and the resulting tooth loss has required searching for new rehabilitation alternatives in Dentistry. Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. Objective: To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. Material and methods: The following databases were searched: Pubmed, Bireme, Lilacs, and Scielo and 30 articles published between 1965 and 2013 were found using the following descriptors: “dental implants”, “maxillary sinus”, and “biocompatible materials”. Results: Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. In recent years, morphogenetic protein has presented a large clinical use. Conclusion: Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face.

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